Gabapentin, a medication approved for epilepsy and nerve pain, is also prescribed off-label for conditions such as anxiety and sleep disorders. Its use has increased significantly, with prescriptions more than doubling between 2009 and 2016. While gabapentin is considered non-addictive, withdrawal symptoms can occur if the medication is stopped abruptly, particularly at high doses or after long-term use.
Withdrawal symptoms from gabapentin may include physical effects like sweating, nausea, headaches, dizziness, fatigue, and body aches. Psychological symptoms can involve irritability, anxiety, depression, restlessness, and mood swings. Sleep disturbances such as insomnia and vivid dreams are also common during withdrawal. Some individuals may experience a rebound effect where original symptoms return or worsen.
The onset of withdrawal typically occurs within 12 to 48 hours after the last dose. Symptoms often peak around days two to three and generally improve over one to two weeks. However, the duration and intensity of withdrawal can vary depending on factors like dosage and individual physiology.
Medical professionals recommend tapering off gabapentin gradually under the supervision of a healthcare provider to minimize withdrawal risks. “The tapering schedule may vary even for two different people who are on the same exact dose. There are multiple factors considered when deciding on how to lower the dose including what other medications you are taking, age, medical conditions and previous side effects you may have encountered with this class of medications,” said Talkspace therapist Dr. Dion Metzger, MD.
Managing withdrawal involves maintaining hydration and nutrition as well as using calming techniques such as mindfulness-based stress reduction (MBSR), deep breathing exercises for anxiety, meditation, or gentle movement like yoga. In some cases, short-term use of supplements or other medications may be recommended by a doctor to address specific symptoms.
“Withdrawal-related anxiety may require you to take medication as needed to help the acute symptoms you’re experiencing. Withdrawal-related depression may be reduced by increasing the dose of any mood medication you may also be taking,” added Dr. Metzger.
While most withdrawal symptoms are manageable with proper care and support from healthcare providers or therapists such as those at Talkspace, severe reactions—such as suicidal thoughts or seizures—require immediate medical attention.
Talkspace offers support for individuals transitioning off gabapentin by providing access to licensed psychiatric providers who can assist with evaluation and prescription management online.